Loading

Walter Flato Goodman Center for Comparative Medical Genetics

Medical genetics is the broad field of science that deals with the role of genes in disease. This involves the identification and characterization of genes that cause disease, as well as the application of genetic knowledge to the diagnosis, treatment, and prevention of genetic diseases. Genetic diseases include disorders in which a single gene mutation is both necessary and sufficient to cause the disease, as well as complex disorders involving the interactions of multiple genes and other factors.

Essentially all of the genetic diseases that occur in humans can be expected to occur in other mammals due to the basic homology between the human genome and the genomes of other mammalian species. However, the recognition of genetic disorders in animals depends upon the degree of medical surveillance utilized and the amount of family information that is available. Domestic animals, particularly the dog and cat, are a rich source of potential models because they are examined by veterinarians for individual diseases at a level that is comparable to human medicine.

The Walter Flato Goodman Center for Comparative Medical Genetics (CCMG) is designed to foster interdisciplinary research and research training in this field through the development of shared resources. The investigators focus their research primarily on naturally-occurring genetic diseases of animals that are true homologs of human genetic diseases.

The CCMG dates from 1974 when an Animal Models Core was funded through the NIH Human Genetics Center grant. In 1985 a grant was awarded by the NIH National Center for Research Resources (NCRR) to establish the National Referral Center for Animal Models of Human Genetic Disease, which is the main mechanism through which new genetic diseases are identified and characterized. The multi-departmental Section of Medical Genetics was the forerunner and model for the center concept developed in the School of Veterinary Medicine in the 1990’s. The program was formally designated as the Center for Comparative Medical Genetics in 1994. Dr. Donald Patterson was the founder and director of this program for 25 years until his retirement in 1998, when Dr. Wolfe was appointed to succeed him. In 2003 Mr. Walter Flato Goodman committed an endowment for future support of the center and it was named in his honor. Mr. Goodman is a long time dog breeder, judge, and member of the American Kennel Club. He is also a member of the Board of Overseers of the School of Veterinary Medicine.

Investigators at Penn's Veterinary School have been at the forefront of comparative medical genetics research for over three decades. The contributions fall into two broad categories in terms of application of the knowledge gained: 1) contributions to the diagnosis and control of genetic diseases within animal populations, particularly the dog and cat; and 2) contributions to the understanding and treatment of human disease using the animal homologs as models for research in areas such as gene therapy. This includes the discovery of more than 50 new animal homologs of human genetic diseases in various species. Many of the findings have been published in leading scientific journals. Scientists in the CCMG have been highly successful in attracting grant funding from federal and private sources. Since genetics is basic to all disciplines in the medical specialties and the basic biological sciences, the CCMG investigators interact with faculty and programs throughout the Veterinary School and the University.

The investigators in the CCMG interdisciplinary are drawn from several departments of the School of Veterinary Medicine and the School of Medicine. The investigators also have numerous collaborations within the University and at other universities, research institutes, biotechnology companies, NIH, and internationally. The CCMG members have key roles in University-wide programs including graduate groups in Cell and Molecular Biology, Biochemistry and Molecular Biophysics, Immunology, and Neuroscience; The David Mahoney Institute of Neurological Sciences; The Mental Retardation Research Center; Abramson Family Cancer Research Institute; and the Penn Genomics Institute. The programs within the CCMG fall into three general categories.

Studies in Established Animal Models of Human Genetic Disease

  • These studies are aimed primarily at the investigation of new approaches to understanding and treating the corresponding disease in human patients. Current studies include comparative mapping of disease genes in the dog, studies of the pathogenesis of genetic diseases in dogs and cats, and gene therapy studies in mice, cats, and dogs. Link to the Faculty Research This work contributes basic knowledge needed in both veterinary and human medicine to define the molecular nature of genetic diseases, and to understand the intermediate steps between the disease gene and the clinical and pathologic phenotype in affected individuals. These are primarily conducted through individual research grants, mostly from NIH. Many of these grants involve collaborations among the CCMG laboratories.

Clinical Genetics Research

  • This research concentrates on the identification of naturally occurring genetic diseases of animals and characterization of these diseases at the clinical, pathologic, and molecular genetic levels. One objective is to provide the basic knowledge needed to provide useful animal models of disease for further investigation. Potential new genetic diseases are diagnosed and initially characterized under an NCRR Center Grant. The second objective is to use the research information to accurately diagnose and reduce the frequency of genetic disorders within the animal populations in which they occur. This is done in the Josephine Deubler Genetic Testing Laboratory, utilizing a variety of DNA and other tests, as a service to the veterinary, and dog and cat breeding communities. A comprehensive computerized knowledge base on genetic diseases of the dog, The Canine Genetic Disease Information System, is a computerized database that has been developed by Dr. D.F. Patterson and is expected to assist veterinarians, geneticists, and dog breeders in eliminating disease-producing genes from breed populations.

The frontiers of medical genetics and molecular medicine are only limited by the lack of understanding of many fundamental disease processes and the ability to manipulate biological processes by recombinant DNA technologies. The benefits will be applicable directly to domestic animal diseases and the focused investigation of carefully chosen animal diseases will provide key information. The major directions for future research will be in the following areas:

Comparative Genomics

  • Finding and Characterizing Disease Genes in Animals

    The development of methods to map mammalian genomes has revolutionized the approach to identification, isolation and characterization of the mutations that underlie genetic diseases. Recent advances in genome sciences methods have made it more practical to use this approach in the dog and cat. The detection and study of a large variety of disorders with recessive and complex patterns of inheritance is greatly facilitated in the dog and cat because there is enough periodic inbreeding to reveal these defects, but the alleles that confer susceptibility still exist in sufficient frequencies in these populations to be available for study. Breeds of dogs and cats have the same advantages for such studies as human genetic isolates, but the number and diversity of the isolates (breeds) are many times greater than is found in the world’s human population. This is a resource in comparative medical genetics that is waiting to be mined for the purpose of better understanding of human disease, as well as for the improvement of animal health. This effort in the CCMG is focused on avenues of research where the animal models offer unique ways to investigate the genetics and biology. The diseases to be studied are selected for the medical characteristics, the underlying pathology, where the inheritance is sufficiently well documented that a focused investigation can be performed, and where scientific progress can be accelerated by studying the animal disease. Link to PGI (Genomics Institute)

Mechanisms of Disease

  • Understanding the Cellular and Molecular Basis of Pathology

    Although new disease-causing genes are being identified at a rapid rate, there are great gaps in knowledge of how the mutant genes cause the observed clinical and histopathological abnormalities. Animals with specific genetic diseases constitute a major resource for studying the natural history of rare disorders. Because cohorts of sufficient sizes can be studied, various stages of disease progression can be evaluated. Many studies on animal models have been instrumental in improving understanding of the human disease, where it is often impossible to obtain affected tissues during the course of the disease. In addition, a thorough understanding of the molecular and cellular abnormalities of each disease is critical for the rational design of new therapies.

Gene Therapy

  • Using Gene Based Approaches to Treatment

    Advances in molecular biology are being developed into entirely new methods of treating disease. The concept of gene therapy for single gene inherited disorders is compellingly simple: treat a disease at the fundamental level of the DNA defect by inserting a normal copy of the gene into the affected cells of a patient to correct the biochemical deficiency responsible for the symptoms. However, after more than15 years of investigation by many laboratories, this goal remains elusive. It has been particularly difficult to scale up the methods from rodents to large mammals, including humans. The animal models being studied by CCMG investigators provide experimental platforms for understanding the problems of delivering genes successfully to a large mammal under actual disease conditions. In veterinary clinical medicine the best treatment for these very rare disorders will be to remove the mutant allele from the breeding stock. However, there are a number of diseases of veterinary importance where gene transfer methods may be applicable, e.g. cancers, degenerative joint disease in horses, neurologic abnormalities, and common metabolic diseases such as diabetes. Effective application in a clinical setting will depend on having a thorough understanding of the underlying biochemical, cellular, and pathologic mechanisms of each disease.

Biological Imaging

  • Direct viewing of Life Processes, Pathology and Treatment

    Biological imaging using noninvasive methods is changing the landscape not only of clinical medicine but of research into biological processes in their natural settings. CCMG investigators use techniques such as NMR to study the progression of disease and responses to treatments and to gain new insight into pathologic mechanisms. Future research in this area will be done in close collaboration with the Metabolic Magnetic Resonance Research and Computing Center and the Department of Radiology in the School of Medicine to take advantage of the infrastructure, expertise, and instrumentation that is available to the biomedical community at Penn.

The Walter Flato Goodman Center for Comarative Medical Genetics is defined by its renown faculty and their research:

Team
  Name & Title Research Description
  Gustavo D. Aguirre, VMD, PhD, Professor of Opthalmology Inherited retinal degeneration disease: This laboratory studies the inheritance of retinal degeneration in dogs as a model for human diseases. These include efforts to identify the genes and locate the mutations associated with several separately inherited forms of progressive retinal atrophy (PRA), a significant disease of dogs that is also the genetic analog of retinitis pigmentosa, a group of retinal degenerations inherited in human families. This laboratory is involved in the construction of the dog genome map and is also using genomics analysis to map behavioral traits in canids.
  David Artis, PhD, Professor of Immunology & Microbiology Regulatory mechanisms controlling immune cell homeostasis: The long-term goals of the Artis lab are to understand the regulatory mechanisms that control immune cell homeostasis at barrier surfaces. Employing diverse models of microbial colonization, pathogen infection and chronic inflammation, we are examining how innate and adaptive immune responses are regulated in the skin, lung and intestine. Over the last fifteen years, Artis has developed expertise in examining how microbe-specific T helper cell responses develop and are regulated following infection.
  Michael L. Atchison, PhD, Professor of Biochemistry Understanding basic gene function: The laboratory is interested in the molecular mechanisms responsible for transcriptional regulation and the control of differentiation. Chromatin structure and histone acetylation are also important components of gene regulation. Other studies are directed towards transcriptional activation, transcriptional repression, and association with the nuclear matrix. These basic studies on gene regulation are conceptually important for understanding normal gene function, developmental disorders, and control of transferred genes in specific cell types.
  Narayan G. Avadhani, PhD, Professor of Biochemistry Nuclear and mitochondrial gene interaction: The research in this laboratory is focused on understanding the nature of biochemical and genetic signals which accurately coordinate the expression of the 16 kb mitochondrial genome and a number of tissue specific, as well as ubiquitously expressed, genes that encode various mitochondrial proteins in animal cells. Recent studies indicate that mitochondrial functions are critical in the pathogenesis of neurodegenerative conditions such as Alzheimer’s disease.
  Tracy L. Bale, PhD, Professor of Neuroscience Understanding diabetes and obesity: The laboratory's research applicable to the DERC is focused on understanding the central programming and pathways underlying a predisposition to diabetes and obesity. We have developed mouse models examining maternal obesity, caloric restriction, and chronic stress to determine target genes and epigenetic mechanisms involved in disease.
  Kendra K. Bence, PhD, Professor of Neuroscience Understanding diabetes and obesity: The goal of our research is to examine the cellular mechanisms by which protein tyrosine phosphatases regulate obesity and diabetes. Currently, we are investigating how tissue-specific protein tyrosine phosphatase 1B (PTP1B)-deficiency mediates effects on body weight and insulin sensitivity. PTP1B is an important negative regulator of both the insulin and leptin signaling pathways in tissues such as liver, muscle and brain. PTP1B-/- mice are lean and have increased energy expenditure, as well as improved glucose homeostasis. We hypothesize that some of the phenotypes seen in PTP1B-/- mice are due to leptinindependent effects.
  Jean Bennett, MD, PhD, Professor of Ophthalmology Gene therapy retinal diseases: This laboratory studies gene therapy approaches to eye diseases, particularly the retina. In collaboration with Dr. Aguirre’s group, they performed the first successful gene therapy for an inherited blindness in a dog model. Those studies were the basis for proposing a clinical trial. Additional studies focus on diseases causing abnormal blood vessel growth, such as diabetic retinopathy and retinopathy of prematurity. The laboratory is also using somatic gene transfer to develop animal models for other specific blinding diseases and to develop methods of rescuing vision.
  Ralph L. Brinster, VMD, PhD, Professor of Physiology Biology of reproductive cells: The research in this laboratory is directed towards understanding the fundamental events involved in germ cell development and differentiation. A seminal accomplishment was the development of methods for germ-line gene transfer, which has been used to elucidate fundamental mechanisms of gene expression and the roles of genes in development and differentiation. The research currently focuses on the biology of the spermatgonial stem cell, which is responsible for the continuity of spermatogenesis in the adult male.
  Michael Cancro , PhD, Professor of Pathology and Laboratory Medicine B lymphocyte development: This laboratory studies innate mechanisms of B-cell immune responses. They are interested in how the innate immune system develops, how it functions in response to pathogenic organisms, and how it changes with age. Work from this laboratory has defined the developmental stages spanning immature B cell formation in the bone marrow to final maturation in the periphery and now focuses on the molecular basis for survival and differentiation within developmental subsets. Normal and mutant mice are used in the studies that focus on specific receptor systems and how age-related alterations in both intrinsic and micro-environmental factors affect innate immunity.
  Peter J. Felsburg, VMD, PhD, Professor of Immunology Inherited defects of the immune system: This laboratory studies inherited defects of the immune system. Clinical research in the WFG-CCMG led to the discovery of a form of severe congenital immune deficiency with X-linked recessive inheritance in the dog. The dog disease involves the same gene as that involved in human X-SCID, the most common form of inherited immune deficiency in children. The model is being used to study basic questions of immune system development, as well as potential treatments such as bone marrow transplantation and gene therapy.
  Nigel W. Fraser, PhD, Professor of Microbiology Molecular mechanisms of herpesvirus latency: The research in this laboratory is directed towards understanding the mechanism of herpes simplex virus latency and reactivation. There is also interest in the use of herpes viruses as a vector for gene therapy in the CNS, which is being done in collaboration with Dr. Wolfe. Studies using replication restricted HSV as a therapy for tumor destruction are also being performed. All of these strategies are potentially useful in clinical veterinary medicine as well as human patients.
  Kurt David Hankenson, DVM, PhD, Professor of Cell Biology Gene-targeted and transgenic murine models: This laboratory has extensive experience working with gene-targeted and transgenic murine models and in the cellular and molecular aspects of osteoblastogenesis. Dr. Hankenson’s laboratory studies the regulation of mesenchymal progenitor differentiation and maintenance of progenitor cell stemness, focused primarily on extracellular mediators of osteoblast differentiation (growth factors and ECM). His work is particularly focused on the contribution of mesenchymal-derived cells to bone regeneration and maintenance of bone formation to build and maintain adult bone mass.
  Mark E. Haskins, VMD, PhD, Professor of Pathology Lysosomal storage diseases: This laboratory focuses on lysosomal storage diseases. The WFG-CCMG has identified animal models of several of these disorders, each involving a separate enzymatic defect. The animals are accurate models of the human diseases and have provided significant new insights into the natural history and mechanisms of pathogenesis. The primary interest of this laboratory is in the pathology and treatment of bones, joints and visceral organs. The animal models have been used extensively for experiments in bone marrow transplantation, enzyme replacement, and gene therapy.
  Katherine A. High, MD, Professor of Pediatrics Molecular biology of hemophilia: This laboratory studies hemophilia B, caused by deficiency of clotting factor IX. Successful gene therapy experiments in the dog model provided the basis for initiating human clinical trials. However, obtaining therapeutic levels in human patients has been elusive. Other dog models exist with different mutations that are especially valuable to study as counterparts to human patients, particularly for the immune response (mis-sense CRM-positive vs. nonsense CRM-negative mutations) to better understand the response to gene-transferred clotting factors.
  Christopher A. Hunter, PhD, Professor of Pathology Host immune responses to Toxoplasma gondii: This laboratory studies host-pathogen interactions through both innate and adaptive immunity. They focus on host responses to the parasite Toxoplasma gondii, which is an important opportunistic infection in immuno-compromised patients. Studies are directed at early post-infection events of innate immune mechanisms, at understanding how protective adaptive immunity is mediated in the brain, and understanding the importance of different intra-cellular signaling pathways in controlling the immunity.
  Andras M. Komaromy, Dr.med.vet., PhD, Professor of Ophthalmology Gene therapy of cone photoreceptor: This group is working on the study of molecular and cellular disease mechanisms and gene therapy of cone photoreceptor. This work is being supported by the grant R01-EY019304. Trainees enrolled in the program will be involved in all aspects of our research.
  Gary A. Koretzky, MD, PhD, Professor of Pathology and Laboratory Medicine Signal transduction in immune cells: This laboratory focuses on understanding the important role T lymphocytes and other cells of the immune system play in combating infection and destroying cancerous tissue. Through specific receptors on their surface, these cells recognize infected or transformed malignant tissue. This recognition stimulates those receptors on the immune cells, initiating a cascade of biochemical events, the process known as signal transduction.
  Carolina B. Lopez, PhD, Professor of Pathobiology Innate immune response to virus infection: Our laboratory studies the innate immune response to virus infection. We have contributed to the understanding of the immune response to influenza and Sendai virus and of the mechanisms that govern viral recognition by immune cells. We have extensive experience using the influenza and Sendai virus models of infection in mice. We recently demonstrated that during the early phase of the anti-viral immune response to respiratory viruses the lung interacts with cells localized in the distal bone marrow to coordinate the appropriate response.
  Phillip A. Scott, PhD, Professor of Immunology Spectral immunity: This laboratory investigates the host factors that determine the nature of the immune response that develops after natural infection or immunization, using parasitic infection of mice as a model system. The genetic composition of the host directly influences the type of response that develops, thus different mouse strains are used to dissect the molecular mechanisms. The main focus is on cytokine regulation of host responses to infection, including evaluation of how the protective effects of cytokines can be dissociated from potential toxic effects of the molecules.
  Gary Smith, D.Phil, Professor of Population Biology & Epidemiology Epidemiology of parasitic and infectious diseases: Our laboratory studies the use of mathematical modeling techniques to facilitate the control of infectious and parasitic disease. Areas of interest include parasite population biology; the epidemiology of parasitic diseases (including those caused by viruses and bacteria); mathematical modeling of parasitic diseases of veterinary and medical importance; and economic evaluation of chemotherapeutic and vaccination strategies.
  Hansell H. Stedman, MD. Associate Professor of Surgery Gene transfer for muscular dystrophies: This laboratory is developing novel surgical approaches to deliver genes via the vascular system to target large masses of skeletal and cardiac muscle. The goal is to treat disorders such as Duchene muscular dystrophy (DMD) and limb girdle muscular dystrophy, and cardiomyopathy. Significant progress has been made towards achieving transduction in high percentages of the muscle fibers in larger dogs. These studies are now being performed with therapeutic genes in the dog disease models to assess the physiological effects.
  Charles H. Vite, DVM, PhD, Assistant Professor of Neurology Imaging and pathology of neurogenetic disease: This investigator is interested in non-invasive imaging of neurological diseases using magnetic resonance imaging (MRI) methods. The laboratory has developed MR methods for quantitative measurements of dysmyelination in the Niemann-Pick C and the alpha-mannosidosis cat. Current research is directed to developing more sensitive methods to analyze pathology in the CNS, such as diffusion weighted imaging and spectroscopy. The long-term goal is to develop strategies to understand neurological diseases in situ, as well as to follow the natural progression of the diseases and responses to experimental therapies.
  James M. Wilson, MD, PhD, Professor of Medicine Gene therapy in liver and lung: Dr. Wilson is interested in the development of effective gene therapies for inherited diseases, such as cystic fibrosis, muscular dystrophies, and inborn errors of metabolism in the liver and lung. Therapeutic interventions focus on the development of novel and improved somatic gene transfer methodologies. The studies utilize vectors primarily based on adeno-associated virus and other DNA viruses. This laboratory has developed a number of novel vectors by incorporating variant envelope and capsid proteins into vectors to alter their host and tissue tropism.
  Beth Ann Winkelstein, PhD, Professor of Bioengineering & Neurosurgery Biomechanics to animal models of pain: This group has continued to investigate the relationships between soft and neural tissue loading and pain by developing cervical models of nerve root and facet joint injury and integrating that work with tissue biomechanics. Over that period, I expanded my research to include collaborations focused on clinical diagnostics and treatments and have implemented bioengineering approaches such as small animal imaging and controlled-release of drug delivery in our models. As PI or Co-Investigator on several NIH-, NSF-, CDC-, industry-, foundation- and university-funded grants, I have integrated biomechanics and cellular biology techniques in vivo, in vitro and using cadaver, computational and human models to investigate pain mechanisms.
  John H. Wolfe, VMD, PhD, Professor of Pathology Gene therapy for the central nervous system: This laboratory investigates direct gene transfer and neural stem cell engraftment in the CNS. Various vector systems and routes of delivery are being tested using animal disease models as a platform to evaluate therapeutic effectiveness. Most of the work has centered on the lysosomal storage diseases that, like most inherited metabolic disorders in the CNS, have global lesions. Advances in treatment of the mouse CNS are being extended to the dog and cat models to study the significant scale-up barriers that must be overcome to effectively treat the human brain. This lab is also pursuing studies on reporter genes for non-invasive imaging by PET and MRI in the brain.
Program Faculty
  Name & Title Research Description
  Margret L. Casal, Dr. med. vet., PhD, Assistant Professor of Medical Genetics Inherited skin diseases: Dr. Casal is investigating inherited skin diseases. X-linked hypohidrotic ectodermal dysplasia (HED) is the most common developmental disorder affecting the skin and its appendages in humans. This laboratory is studying the genetic, molecular, and developmental basis of canine HED. Several other canine models of human genodermatoses (junctional epidermolysis bullosa, ichthyosis, black hair follicular dysplasia, and lupoid dermatosis) have also been identified in the dog, which are at various stages of characterization. These diseases provide an unparalleled group of models for investigation.
  Diane Joyce Gaertner, DVM, Professor of Pathobiology Laboratory Animal Medicine: The goal of this T-32 grant is to train veterinarians in research. I serve as the academic and administrative leader for laboratory animal medicine for Penn and I also lead the Division of Laboratory Animal Medicine training program for residents in laboratory animal medicine. My professional mission at this career stage is to lead a strong program of laboratory animal care and to train veterinarians in laboratory animal medicine and research. Research education is a key component in training veterinarians to serve on a continuum between leading a research program as a PI and leading academic programs of laboratory animal care.
  Urs Giger, PD Dr. med. vet., Professor of Medical Genetics Metabolic and blood diseases: This laboratory studies inherited metabolic and blood diseases. The research focuses on the clinical, pathological, and genetic characterization of the disorders, as well as their treatment including transfusion support strategies. A major focus is the search for new models of hereditary disorders in dogs and cats, which represent homologues of human genetic diseases, including enzyme deficiencies, and blood cell and hemostatic defects. Significant effort is directed towards understanding the biochemical basis of genetic diseases and variants of mutations.
  Paula S. Henthorn, PhD, Professor of Medical Genetics Identification of disease causing genes: This laboratory is involved in characterizing mutations in disease causing genes in a number of large animal models, currently focused on identifying genes involved in complex patterns of inheritance. The main model is congenital heart malformations in the dog, which constitutes one of the largest classes of human birth defects. The pioneering studies of D.F. Patterson showed that the most common forms are essentially the same in humans and dogs, and are genetically determined. Studies are directed towards gene mapping, identification of specific genes in the canine model, and correlating the specific understanding of the developmental events.

 

Grant Support

Research Grants

Faculty
Member
Faculty Member Role on Project and Grant Title
Source of Support
Grant Number and Status
Aguirre, G Translational Research for Retinal Degeneration Therapies NIH EY-017549
Aguirre, G Retinal remodeling in canine models of LCA/early onset RD The Foundation Fighting Blindness
Aguirre, G NDC for the Optical Control of Biological Function NIH EY-01-8241
Artis, D Functional biology of IL-25 following helminth infection NIH AI-074878
Artis, D Immuno-regulation of GI nematode infection NIH AI-061570
Artis, D Epithelial cell regulation of intestinal immune homeostasis NIH AI-083480
Artis, D Functional Biology of Intestinal Epithelial Cells in Food Allergy NIH AI-087990
Artis, D Tracking helminth-specific immune responses in vivo Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Diseases
Atchison Control of B Cell Development by YY1 NIH AI-079002
Atchison Development control of enhancer function NIH GM-082841
Avadhani, N Role of Mitochondrial Respiratory Stress Signaling in Cancer Progression NIH CA-022762
Avadhani, N Role of Mitochondrial Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury NIH AA-017749
Avadhani, N SUPPLEMENT- Role of Mitochondrial Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury NIH AA-017749
Avadhani, N Mechanisms and Functions of Bimodally Targeted Cytochrome P450S to Mitochondria NIH GM-034883
Bale, T Actions of CRF on 5-HT pathways in mood regulation NIH MH-073030
Bale, T Early pregnancy stress programming of offspring emotionality NIH MH-087597
Bale, T Early gestation as a sensitive period to stress in sex-dependent neurodevelopment NIH MH-091258
Bence Neuronal protein tyrosine phosphatases in metabolism NIH DK 082417
Bennett, J Gene therapy for LCA due to CEP290 mutations Donor: Project CEP290
Brinster, R Regulation of Mouse Spermatogonial Stem Cell Self-Renewal NIH HD052728
Brinster, R Altering the Genes of Farm Animals Kleberg Foundation
Cancro, M Spinal Cord Injury and Immune Response to Viral Pathogen Nielsen Foundation
Cancro, M Mechanisms regulating plasma cell persistence in health and autoimmunity Department of the Army W81WWXWH-10-1-0185
Cancro, M Transitional B cell selection during peripheral B lymphopenia and reconstitution NIH AI-073939
Cancro, M Lymphocyte homeostasis and regulation during aging NIH AG-030227
Cancro, M Effects of induced B lymphopenia on homeostasis, selection, and immunity Human Genome Sciences, Inc.
Felsburg, PJ Gene Therapy for Canine X-linked SCID NIH AI-043745
Fraser, N Gene Transfer to and Expression in Neurons in Vivo NIH NS-029390
Fraser, N Mechanism of Latency of Herpes Simplex Virus NIH NS-033768
Fraser, N Gene Transfer to and Expression in Neurons in Vivo NIH NS-029390
Hankenson BMP6 Induction of Human Mesenchymal Stem Cell Osteoblast Differentiation NIH DE-017471
Hankenson Endosteal Adipose in Age-Associated Osteopenia NIH AR-028922
Hankenson Notch signaling in bone regeneration Osteosynthesis and Trauma Care Foundation
Hankenson Notch signaling in bone regeneration Department of Defense (DOD) Peer Reviewed Orthopaedic Research Program (PRORP) Office of the Congressionally Directed Medical Research Programs (CDMRP).
Hankenson Delivery of R-spondin2 using osteogenic biomaterials Veterans Administration (VA) Merit Grant program
Hankenson Notch Signaling in Bone Regeneration Institute of Aging.  University of Pennsylvania
Haskins, ME Gene Therapy of Mucopolysaccharidosis VII NIH DK-054481
Haskins, ME Gene Therapy in Alpha-Mannosodosis NIH NS-061809
Haskins, ME Animal Models of Human Genetic Diseases NIH RR-02512
High, KA Gene Therapy for Hemophilia using Muscle Expressed FVIIa NIH HL-106300
High, KA Pathway to Accelerate Clinical Development in Gene Transfer: cGMP Vector Core NIH RR-030997
Hunter, C Role of dendritic cells in resistance to T. gondii NIH AI-071302
Hunter, C Immunopathogenesis of Toxoplasmic Encephalitis NIH AI-41158
Hunter, C Regulation of the early immune response to Toxoplasma gondii NIH AI-42334
Hunter, C Understanding how IL-27 affects infection-induced responses by Treg cells. Centocor
Hunter, C Role of chemokines in the T cell response to ocular toxoplasmosis. NIH EY-021314
Komaromy, AM Achromatopsia - Disease Mechanisms and Cone Directed Gene Therapy NIH EY-017549
Koretszky, G Novel Substrates of the TCR Kinase NIH GM-53256 (MERIT)
Koretszky, G Project Leader (Project 1), Core Director (Core A) Temporal and Spatial Organization of Signaling complexes in T and B Cells NIH CA-93615
Lopez, Christina A novel virus-derived adjuvant NIH AI-0803284
Lopez, Christina Lung and bone marrow crosstalk during a respiratory viral infection NIH AI-0803481
Lopez, Christina Initial study of the dendritic cell response to defective viral particles NIH AI-080917
Schifferli The Psa fimbriae of Yersinia pestis, an adhesin with protective immunogenic properties NIH AI-076695
Schifferli Correlation of Salmonella colonization factors and antibiotic resistance by next generation sequencing. University Research Foundation
Schifferli Allelic diversity of Salmonella colonization and antibiotic resistance genes Veterinary Center for Infectious Disease Research
Scott IL-12 As an Immunopotentiator in Leishmaniasis NIH AI-035914
Scott Initiation of Immune Response in Chronic Leishmaniasis NIH AI-076257
Scott Myeloid Lineage Cells and Immunopathology in Leishmania NIH AI-088650
Stedman, H Systemic Molecular Therapy for Muscular Dystrophy NIH NS-042874
Stedman, H Shared Resource for Disease – Model Surgical Critical Care & Data Mgmt. NIH
Stedman, H Fecal DNA Biomarkers in Screening for Pancreatic Research AACR
Vite Collaborator; Gene Transfer & NMR studies in alpha-mannosidosis brain NIH DK-63973
Vite Intrathecal cyclodextrin therapy of feline Niemann-Pick type C disease NIH NS-073661
Vite Safety, Performance, and Efficacy of a Seizure Advisory System in Dogs with Epilepsy: A Pilot Study NeuroVista Inc
Vite Enzyme Replacement Therapy in Krabbe Disease in Dogs Shire Pharmaceuticals Inc
Wilson, JM Molecular Therapy for Cystic Fibrosis and Genetic Diseases NIH DK-047757
Wilson, JM DNA Virus as Vectors for Cardiovascular Diseases NIH HL-059407
Wilson, JM Gene Therapy Resource Program - Preclinical Vector Production HHSN-268200748202C
Wilson, JM Gene Therapy for Urea Cycle Disorders NIH HD-057247
Wilson, JM Regulated Transgene Expression in the Retina NIH EY-020274
Wilson, JM The Impact of Adenovirus Infections on HIV-1 Vaccine Performance Gates Foundation 51061
Wilson, JM Research Development Program– CF Pathophysiology and New Therapies CFF-R881-CR07
Wilson, JM AAV Vector Development ReGenX  LLC
Winkelstein Biomechanics of Neck Pain: Does Form Dictate Function? NSF, BES (CAREER 0547451)
Winkelstein NSF-GOALI Award NSF –GOALI Award
Winkelstein Nociceptive Mechanisms in Whiplash Injury NIH AR-056288
Winkelstein Electrophysiological Methods for Understanding Chronic Pain in Vivo University Research Foundation Award- University Pennsylvania
Winkelstein Building Interdisciplinary Research Teams BIRT-AR-551895
Winkelstein Salmon Thrombin as a Treatment to Attenuate Acute Pain & Promote Tissue Healing by Modulating Local Inflammation DOD, CDMRP-HDA #OR090700
Winkelstein Development of a Novel Translational Model of Vibration Injury to the Spine to Study Acute Injury in Vivo DOD, CDMRP-TDA #OR090496
Winkelstein Cervical Spine Human Surrogate Mechanical Investigations US Army Research W911NF-07-D-0001
Wolfe Gene transfer & NMR studies in alpha-mannosidosis brain NIH DK-063973
Wolfe Stem cell transplantation for neurogenetic disease NIH NS-056243
Wolfe Gene transfer to and expressions in neurons NIH NS-029390
Wolfe Pilot project: AAV vector gene transfer to manipulate the pontine micturition circuit NIH DK-052620
Wolfe Program in Comparative Animal Biology; Clinical and Translational Science Award NIH RR-024134
Wolfe AAV vector transduction in the brain in animal models of a lysosomal storage disease NIH NS-038690

Training Grants

Program Director
Title of
Training Grant
Funding Source Including Identifying Number
Atchison Short-term Training: Students in Health Professional Schools NIH RR-007065
Atchison

 

 

VMD-PhD training in infectious disease-related research NIH AI-070077
Cancro MP Immune System Development and Regulation NIH AI-055428
Gaertner, DJ Translational Research and Laboratory Animal Medicine Education for Veterinarians NIH RR-032017
High K Pediatric Hematology Research Training Program NIH HL- 007150
Hunter CA Parasitology: Modern Approaches NIH AI-007532
Koretzky GA Training Program Rheumatic Disease NIH AR-007442
Wolfe JH Training in Comparative Medical & Molecular Genetics NIH RR-07063
Wolfe JH Gene Therapy Training: CF & Genetic Diseases NIH DK-007748