Establishing gene and cell therapies to improve cartilage repair and prevent osteoarthritis using the horse as a model for human joint disease
Establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects
Immunomodulation of the posttraumatic joint using intra-articular adeno-associated virus (AAV) gene therapy
Mechanisms of post-traumatic osteoarthritis (PTOA)
Ortved KF, Austin BS, Scimeca MS, Nixon AJ RNA interference mediated interleukin-1ß silencing in inflamed chondrocytes decreases target and downstream catabolic responses. Arthritis : , 2016.Griffin D, Ortved KF, Nixon AJ, Bonassar L Mechanical properties and structure-function relationships in articular cartilage repair using IGF-I gene therapy. Journal of Orthopedic Research 34: 149-153, 2016.Ortved KF, Nixon AJ Cell-based cartilage repair strategies for horses. Vet J : 1-12, 2016.Ortved KF, Begum L, Mohammed HO, Nixon AJ. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Molecular Therapy 23: 363-373, 2015.Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I or rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy 26: 161-171, 2015.Ortved KF, Stewart AW, Fubini SL, Hackett RP Surgical treatment of 4 horses for cryptorchidism caused by failure of regression of the cranial suspensory ligament of the testis. Vet Surg 43: 266-270, 2014.Ortved KF, Nixon AJ, Mohammed HO, Fortier LA Treatment of subchondral bone cysts of the medial femoral condyle in mature horses with growth factor enhanced chondrocyte grafts: A retrospective study of 49 cases Equine Vet J 44: 606-613, 2012.Ortved KF Clinical considerations of intestinal entrapment through the gastrosplenic ligament in the horse. Equine Vet Educ 25: 21-22, 2012.Ortved KF, Cheetham J, Mitchell LM, Ducharme NG Successful treatment of persistent dorsal displacement of the soft palate and evaluation of laryngohyoid position in 15 racehorses. Equine Vet J 42: 23-29, 2010.Ortved KF, Krotscheck U, Collins SA, Rawlinson JJ, Dyce J Cementless total hip replacement in an alpaca Vet Surg 38: 583-587, 2009.
DVM (Veterinary Medicine) University of Guelph, 2006PhD (Comparative Biomedical Sciences) Cornell University, 2014