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ENRICO RADAELLI, DVM, PhD
Associate Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine

Diplomate, European College of Veterinary Pathologists (ECVP)

Research Areas: Pathobiology of animal models, Phenotyping of genetically engineered mouse (GEM) models, Comparative pathology
PubMed Link
Contact Information:
 Email enrada@vet.upenn.edu

Pathobiology of animal models
Phenotyping of genetically engineered mouse (GEM) models
Comparative pathology

Olvedy Michael, Tisserand Julie C, Luciani Flavie, Boeckx Bram, Wouters Jasper, Lopez Sophie, Rambow Florian, Aibar Sara, Thienpont Bernard, Barra Jasmine, Köhler Corinna, Radaelli Enrico, Tartare-Deckert Sophie, Aerts Stein, Dubreuil Patrice, van den Oord Joost J, Lambrechts Diether, De Sepulveda Paulo, Marine Jean-Christophe Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma. The Journal of clinical investigation 127: 2310-2325, 2017.

Elia Ilaria, Broekaert Dorien, Christen Stefan, Boon Ruben, Radaelli Enrico, Orth Martin F, Verfaillie Catherine, Grünewald Thomas G P, Fendt Sarah-Maria Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. Nature communications 8: 15267, 2017.

Espuny-Camacho Ira, Arranz Amaia M, Fiers Mark, Snellinx An, Ando Kunie, Munck Sebastian, Bonnefont Jerome, Lambot Laurie, Corthout Nikky, Omodho Lorna, Vanden Eynden Elke, Radaelli Enrico, Tesseur Ina, Wray Selina, Ebneth Andreas, Hardy John, Leroy Karelle, Brion Jean-Pierre, Vanderhaeghen Pierre, De Strooper Bart Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron 93: 1066-1081.e8, 2017.

Dagklis Antonis, Demeyer Sofie, De Bie Jolien, Radaelli Enrico, Pauwels Daphnie, Degryse Sandrine, Gielen Olga, Vicente Carmen, Vandepoel Roel, Geerdens Ellen, Uyttebroeck Anne, Boeckx Nancy, de Bock Charles E, Cools Jan Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. Blood 128: 2642-2654, 2016.

Radaelli E, Castiglioni V, Recordati C, Gobbi A, Capillo M, Invernizzi A, Scanziani E, Marchesi F The Pathology of Aging 129S6/SvEvTac Mice. Veterinary pathology 53: 477-92, 2016.

Leucci Eleonora, Vendramin Roberto, Spinazzi Marco, Laurette Patrick, Fiers Mark, Wouters Jasper, Radaelli Enrico, Eyckerman Sven, Leonelli Carina, Vanderheyden Katrien, Rogiers Aljosja, Hermans Els, Baatsen Pieter, Aerts Stein, Amant Frederic, Van Aelst Stefan, van den Oord Joost, de Strooper Bart, Davidson Irwin, Lafontaine Denis L J, Gevaert Kris, Vandesompele Jo, Mestdagh Pieter, Marine Jean-Christophe Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531: 518-22, 2016.

Adriaens Carmen, Standaert Laura, Barra Jasmine, Latil Mathilde, Verfaillie Annelien, Kalev Peter, Boeckx Bram, Wijnhoven Paul W G, Radaelli Enrico, Vermi William, Leucci Eleonora, Lapouge Gaëlle, Beck Benjamin, van den Oord Joost, Nakagawa Shinichi, Hirose Tetsuro, Sablina Anna A, Lambrechts Diether, Aerts Stein, Blanpain Cédric, Marine Jean-Christophe p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nature medicine 22: 861-8, 2016.

Gallardo Rodrigo, Ramakers Meine, De Smet Frederik, Claes Filip, Khodaparast Ladan, Khodaparast Laleh, Couceiro José R, Langenberg Tobias, Siemons Maxime, Nyström Sofie, Young Laurence J, Laine Romain F, Young Lydia, Radaelli Enrico, Benilova Iryna, Kumar Manoj, Staes An, Desager Matyas, Beerens Manu, Vandervoort Petra, Luttun Aernout, Gevaert Kris, Bormans Guy, Dewerchin Mieke, Van Eldere Johan, Carmeliet Peter, Vande Velde Greetje, Verfaillie Catherine, Kaminski Clemens F, De Strooper Bart, Hammarström Per, Nilsson K Peter R, Serpell Louise, Schymkowitz Joost, Rousseau Frederic De novo design of a biologically active amyloid. Science (New York, N.Y.) 354: , 2016.

Castiglioni V, Farhang Ghahremani M, Goossens S, De Maglie M, Ardizzone M, Haigh J J, Radaelli E Immunohistological Description of Nongestational Ovarian Choriocarcinoma in Two Female Mice With Conditional Loss of Trp53 Driven by the Tie2 Promoter. Veterinary pathology 52: 752-6, 2015.

Radaelli Enrico, Hermans Els, Omodho Lorna, Francis Annick, Vander Borght Sara, Marine Jean-Christophe, van den Oord Joost, Amant Frédéric Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas. PloS one 10: e0124974, 2015.

DVM (Veterinary Medicine) University of Milan (Italy) School of Veterinary Medicine, 2004

PhD (Veterinary Hygiene & Comparative Animal Pathology) University of Milan (Italy) School of Veterinary Medicine, 2010