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DE'BROSKI R. HERBERT, PhD, BS
Associate Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine

Research Areas: Regulatory networks, Immunity, Inflammation, Tissue repair, Mucosal interface, Helminth infection, Lung and intestinal injury, Transgenic mice
PubMed Link
Contact Information:
 Email debroski@vet.upenn.edu

regulatory networks, immunity, inflammation, tissue repair, mucosal interface

Through the study of parasitic helminths and protozoa, my group has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract.

Chan, P. Y., Carrera Silva, E. A., De Kouchkovsky, D., Joannas, L. D., Hao, L., Hu, D., Huntsman, S., Eng, C., Licona-Limón, P., Weinstein, J. S., Herbert, D. R., Craft, J. E., Flavell, R. A., Repetto, S., Correale, J., Burchard, E. G., Torgerson, D. G., Ghosh, S., Rothlin, C. V. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity Science 352: 99-103, 2016.

Nair, M. G., Herbert, D. R. Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages Immunology 148: 115-124, 2016.

Karo-Atar, D., Bordowitz, A., Wand, O., Pasmanik-Chor, M., Fernandez, I. E., Itan, M., Frenkel, R., Herbert, D. R., Finkelman, F. D., Eickelberg, O., Munitz, A. A protective role for IL-13 receptor a 1 in bleomycin-induced pulmonary injury and repair Mucosal Immunol 9: 240-253, 2016.

Hung, L. Y., Sen, D., Oniskey, T. K., Nieves, W., Urisman, A., Krummel, M. F., Herbert, D. R. Macrophage-Dependent Regeneration of Pulmonary Epithelia Requires Trefoil Factor 2 for Wnt Expression J Immunol 196: , 2016.

Nieves, W., Hung, L. Y., Oniskey, T. K., Boon, L., Foretz, M., Viollet, B., Herbert, D. R. Myeloid-Restricted AMPKa1 Promotes Host Immunity and Protects against IL-12/23p40-Dependent Lung Injury during Hookworm Infection J Immunol 196: 4632-4640, 2016.

Fontana, M. F., Baccarella, A., Kellar, D., Oniskey, T. K., Terinate, P., Rosenberg, S. D., Huang, E. J., Herbert, D. R., Kim, C. C. Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections Parasite Immunol 37: 470-478, 2015.

Fontana, M. F., Baccarella, A., Pancholi, N., Pufall, M. A., Herbert, D. R., Kim, C. C. JUNB is a key transcriptional modulator of macrophage activation J Immunol 194: 177-186, 2015.

Apiwattanakul, N., Thomas, P. G., Kuhn, R. E., Herbert, D. R., McCullers, J. A. Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens Med Microbiol Immunol 203: 357-364, 2014.

Herbert, D., Hung, L. Y., Sen, D., Oniskey, T., Kim, C., Krummel, M. Trefoil factor 2 maintains and restores pulmonary function via promoting epithelial repair and M2 activation J Immunol 192: , 2014.

McBerry, C., Dias, A., Shryock, N., Lampe, K., Gutierrez, F. R., Boon, L., De'Broski, R. H., Aliberti, J. PD-1 modulates steady-state and infection-induced IL-10 production in vivo Eur J Immunol 44: 469-479, 2014.

PhD (Immunology) Thomas Jefferson University, 2000

BS (Microbiology) Xavier University of Louisiana, 1994